THE ULTIMATE GUIDE TO PKRRATING

The activated enzyme then phosphorylates its key substrate, the translational initiation issue eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to some conserved loved ones of four protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to different stimuli12, triggering the built-in str